Ha-ras Oncogene and Anticancer Drug Resistance
نویسندگان
چکیده
منابع مشابه
Expression of the c-Ha-ras Oncogene in Mouse NIH 3T3 Cells Induces Resistance to Cisplatin1
The effect of expression of the c-l la-ra.s oncogene on cisplatin (DDP) sensitivity was examined in murine NIH 3T3 cells transfected with the dexamethasone (DEX)-inducible mouse mammary tumor virus promoter linked to an activated c-Ha-rai gene [LTR H-ras(A) cells]. Treatment of these cells with 5 JJM DEX for 24 h induced c-Ha-ras expression and produced an 8.2 ±1.3-fold (SD) increase in DDP re...
متن کاملMolecular-genetic analysis of myc and c-Ha-ras proto-oncogene alterations in human carcinoma.
The results of recent studies on the molecular biology of cancer suggest the abnormal expression of cellular proto-oncogenes in the process of carcinogenesis [1]. The activation of proto-oncogenes, i.e., their conversion into cellular oncogenes, is associated with gene structural alterations and mutations resulting in the unregulated production of oncoproteins, matched by deranged biological fu...
متن کاملMutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.
The importance of mutational activation of the Ha-ras protooncogene in polycyclic aromatic hydrocarbon-induced mouse skin tumors was investigated in a complete carcinogenesis model using repetitive applications of 7,12-dimethylbenz[a]anthracene (DMBA), or in an initiation-promotion model using a single application of dibenz[c,h]acridine (DB[c,h]ACR) or benzo[a]pyrene (B[a]BP) followed by chroni...
متن کاملHyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis.
Although ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context and cooperative events. Here we show that low-level expression of a constitutively active Ha-ras in mouse urothelium induces simple urothelial hyperplasia that is resistant to progression to full-fledged bladder tumors even in the absence of Ink4a/Arf. In stark contrast, doubling of the gene dosage of th...
متن کاملMalignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene.
We have investigated whether the activation of endogenous ras genes is associated with the immortalization or malignant transformation of primary hamster epidermal cells by chemical carcinogens. We have also asked whether transfection of a cloned c-Ha-ras oncogene (pEJ) into a nontumorigenic cell line established from hamster epidermal cells by N-methyl-N'-nitro-N-nitrosoguanidine treatment can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genomic Medicine, Biomarkers, and Health Sciences
سال: 2011
ISSN: 2211-4254
DOI: 10.1016/s2211-4254(11)60006-x